產(chǎn)品名稱：human gene knockout HEK293 cell line
產(chǎn)品規(guī)格：10E6cell/管，2管
產(chǎn)品運(yùn)輸條件：干冰
產(chǎn)品儲(chǔ)存條件和期限：液氮，長(zhǎng)期保存
產(chǎn)品優(yōu)勢(shì)：
? 敲除有保障，無(wú)效退單或重新生產(chǎn)；
產(chǎn)品驗(yàn)收說(shuō)明：
收到細(xì)胞株包裹時(shí)，請(qǐng)立即檢查細(xì)胞株冷凍管是否有解凍情形，若有請(qǐng)立即拍照并通知公司。細(xì)胞株收到后請(qǐng)盡快開(kāi)展實(shí)驗(yàn)，如果想長(zhǎng)期保存請(qǐng)轉(zhuǎn)移至液氮中。
The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in this gene have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for this gene.
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