產(chǎn)品名稱：human gene knockout HEK293 cell line
產(chǎn)品規(guī)格：10E6cell/管，2管
產(chǎn)品運(yùn)輸條件：干冰
產(chǎn)品儲存條件和期限：液氮，長期保存
產(chǎn)品優(yōu)勢：
? 敲除有保障，無效退單或重新生產(chǎn)；
產(chǎn)品驗(yàn)收說明：
收到細(xì)胞株包裹時(shí)，請立即檢查細(xì)胞株冷凍管是否有解凍情形，若有請立即拍照并通知公司。細(xì)胞株收到后請盡快開展實(shí)驗(yàn)，如果想長期保存請轉(zhuǎn)移至液氮中。
The protein encoded by this gene can heterodimerize with mismatch repair endonuclease PMS2 to form MutL alpha, part of the DNA mismatch repair system. When MutL alpha is bound by MutS beta and some accessory proteins, the PMS2 subunit of MutL alpha introduces a single-strand break near DNA mismatches, providing an entry point for exonuclease degradation. The encoded protein is also involved in DNA damage signaling and can heterodimerize with DNA mismatch repair protein MLH3 to form MutL gamma, which is involved in meiosis. This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC).
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