產(chǎn)品名稱：human gene knockout HEK293 cell line
產(chǎn)品規(guī)格：10E6cell/管，2管
產(chǎn)品運(yùn)輸條件：干冰
產(chǎn)品儲(chǔ)存條件和期限：液氮，長(zhǎng)期保存
產(chǎn)品優(yōu)勢(shì)：
? 敲除有保障，無效退單或重新生產(chǎn)；
產(chǎn)品驗(yàn)收說明：
收到細(xì)胞株包裹時(shí)，請(qǐng)立即檢查細(xì)胞株冷凍管是否有解凍情形，若有請(qǐng)立即拍照并通知公司。細(xì)胞株收到后請(qǐng)盡快開展實(shí)驗(yàn)，如果想長(zhǎng)期保存請(qǐng)轉(zhuǎn)移至液氮中。
This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene.
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